Alejandro Gutierrez Selected Research

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)

1/2022	JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia.
12/2018	PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.
10/2018	Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
1/2018	JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
11/2017	TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia.
1/2017	Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.
12/2014	Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.
11/2014	Cyclin C is a haploinsufficient tumour suppressor.
9/2014	Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
4/2014	An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

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Alejandro Gutierrez Research Topics

Disease

24	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 07/2007
18	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2018 - 11/2007
13	Neoplasms (Cancer) 01/2022 - 06/2007
7	Leukemia 01/2022 - 02/2014
2	Breast Neoplasms (Breast Cancer) 03/2011 - 08/2010
1	Starvation 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 11/2020
1	Ganglioneuroma 10/2020
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2020
1	Chromosome Breakage 01/2019
1	Peripheral Arterial Disease 01/2019
1	Genomic Instability 11/2017
1	T-Cell Leukemia (Leukemia, T Cell) 01/2014
1	Hematologic Neoplasms (Hematological Malignancy) 11/2012
1	Chromosome 5q Deletion Syndrome 11/2012
1	Sarcoma (Soft Tissue Sarcoma) 09/2011
1	Liposarcoma 09/2011
1	Colonic Neoplasms (Colon Cancer) 03/2011
1	Sickle Cell Anemia (Hemoglobin S Disease) 02/2010
1	Pathologic Constriction (Stenosis) 02/2010

Drug/Important Bio-Agent (IBA)

6	Pharmaceutical PreparationsIBA 11/2020 - 03/2010
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2011
4	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 07/2009
4	Transcription Factors (Transcription Factor)IBA 12/2018 - 08/2011
3	Asparaginase (Elspar)FDA Link 01/2022 - 01/2019
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 01/2017
2	AsparagineIBA 01/2022 - 11/2020
2	Amino Acids FDA Link 01/2022 - 11/2020
2	Messenger RNA (mRNA)IBA 01/2021 - 08/2011
2	Small Interfering RNA (siRNA)IBA 01/2018 - 02/2014
2	SteroidsIBA 01/2018 - 08/2010
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 10/2015 - 04/2014
2	T-Cell Acute Lymphocytic Leukemia Protein 1IBA 07/2013 - 08/2012
2	Phosphotransferases (Kinase)IBA 05/2013 - 03/2011
2	Gamma Secretase Inhibitors and ModulatorsIBA 03/2010 - 11/2007
1	GlucocorticoidsIBA 01/2022
1	tofacitinibIBA 01/2022
1	Essential Amino AcidsIBA 01/2022
1	Transfer RNA (tRNA)IBA 01/2021
1	CateninsIBA 11/2020
1	MTOR InhibitorsIBA 10/2020
1	exendin (9-39)IBA 01/2019
1	EnzymesIBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Polycomb Repressive Complex 2IBA 12/2018
1	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)IBA 01/2018
1	Basic-Leucine Zipper Transcription FactorsIBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 11/2016
1	BMS-906024IBA 10/2015
1	Histones (Histone)IBA 12/2014
1	Lysine (L-Lysine)FDA Link 12/2014
1	Cyclin CIBA 11/2014
1	venetoclaxIBA 09/2014
1	Antipsychotic Agents (Antipsychotics)IBA 02/2014
1	PhenothiazinesIBA 02/2014
1	Perphenazine (Trilafon)FDA LinkGeneric 02/2014
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2014
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 05/2013
1	InterleukinsIBA 05/2013
1	Ribosomal Proteins (Ribosomal Protein)IBA 11/2012
1	Monoclonal AntibodiesIBA 01/2012
1	afimoxifene (hydroxytamoxifen)IBA 08/2011
1	F-Box ProteinsIBA 03/2011
1	Sorafenib (BAY 43-9006)FDA Link 03/2011
1	Oncogene Proteins (Oncogene Protein)IBA 03/2011
1	Cyclin EIBA 03/2011
1	ABT-737IBA 03/2011
1	Glycogen Synthase Kinase 3IBA 03/2011
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 03/2011
1	Cullin 1IBA 03/2011
1	Estrone FDA Link 08/2010
1	Hormones (Hormone)IBA 08/2010
1	Molecular Chaperones (Chaperone, Molecular)IBA 03/2010
1	17- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA 03/2010
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 03/2010
1	Proteasome InhibitorsIBA 03/2010
1	Histone Deacetylases (Histone Deacetylase)IBA 03/2010
1	Hydroxyurea (Hydrea)FDA LinkGeneric 02/2010
1	Notch1 ReceptorIBA 11/2007
1	enhanced green fluorescent proteinIBA 07/2007
1	Biological ProductsIBA 06/2007

Therapy/Procedure

14	Therapeutics 11/2020 - 07/2009
4	Drug Therapy (Chemotherapy) 12/2018 - 09/2011
3	Transplantation 01/2016 - 01/2012
1	Treatment Delay 08/2015
1	Molecular Targeted Therapy 05/2013
1	Induction Chemotherapy 08/2010